Nonsterile Compounding Techniques for PTCB

Common Compounding Methods

Nonsterile compounding involves preparing medications in dosage forms not commercially available. Common techniques include trituration (grinding powders to reduce particle size), levigation (incorporating a wetting agent to reduce grittiness), and geometric dilution (mixing a small quantity of active ingredient with a larger amount of base in doubling quantities).

Geometric dilution ensures uniform distribution of potent drugs throughout the preparation. Start by mixing the active ingredient with an equal amount of base, then double the amount of base added each time until all the base is incorporated.

Dosage Forms

Common nonsterile compounded dosage forms include capsules, suspensions, solutions, creams, ointments, and suppositories. Each requires specific equipment and techniques. Capsule filling requires a capsule machine and proper powder flow. Suspensions may need suspending agents to keep particles evenly distributed.

Documentation is essential: every compounded preparation needs a compounding log with the formula, ingredients, lot numbers, BUD, and the identity of the compounding personnel.

Review and Practice

Nonsterile compounding appears on the PTCB exam. Study techniques with flashcards and practice with PTCB mini exams.