DEA Form 222: Ordering Schedule II Controlled Substances

What Is DEA Form 222?

DEA Form 222 is the official order form used to purchase or transfer Schedule II controlled substances. It exists to create an auditable chain of custody from manufacturer to pharmacy. While electronic ordering through the Controlled Substance Ordering System (CSOS) is increasingly common, many pharmacies still use paper Form 222, and the PTCE tests your knowledge of both systems.

Who Can Sign Form 222?

Only the DEA registrant (typically the pharmacist-in-charge) or an authorized individual who has been granted power of attorney can sign Form 222. Pharmacy technicians cannot sign these forms. The power of attorney must be filed with the DEA and maintained on-site.

How the Form Works

Form 222 is a triplicate document:

• Copy 1 (brown) - Kept by the supplier (wholesaler)
• Copy 2 (green) - Forwarded by the supplier to the DEA
• Copy 3 (blue) - Retained by the pharmacy (purchaser)

Each form is pre-printed with the pharmacy's name, address, and DEA number. Up to 10 line items can be listed on a single form. The form must be completed in ink or indelible pencil with no erasures or cross-outs.

Handling Errors

If an error is made on Form 222, the form is voided. It cannot be corrected. Voided forms must be retained for DEA records. All copies of a voided form should be marked "VOID" and filed together.

Electronic Ordering (CSOS)

The CSOS system allows electronic ordering of C-II substances using a digital certificate issued by the DEA. It eliminates the need for paper forms and speeds up the ordering process. Records must still be maintained for 2 years.

Record Retention

All Form 222 records and CSOS electronic records must be kept for a minimum of 2 years and be readily retrievable for DEA inspection.

Understanding controlled substance ordering is essential for the federal requirements domain of the PTCE.