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Pulse Oximetry Limits: When the Number Lies

Learn the conditions that make SpO2 readings unreliable.

December 17, 2024

What SpO2 Tells You

Pulse oximetry estimates the percentage of hemoglobin saturated with oxygen. A normal reading is 95 to 100 percent. It is a useful trend tool, but it does not measure ventilation or the quality of oxygen delivery to tissues.

Common Sources of Error

Carbon monoxide binds to hemoglobin and can falsely produce a normal reading. Poor perfusion, cold extremities, nail polish, motion, and bright ambient light can also cause inaccurate values. Severe anemia may produce a normal saturation despite poor oxygen-carrying capacity.

Clinical Judgment

Always treat the patient, not the monitor. A patient with a normal SpO2 but significant respiratory distress still needs oxygen and close monitoring. In suspected carbon monoxide poisoning, give high-flow oxygen regardless of the displayed reading.

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